Table 2 Mean IC50 of Egyptian plant extracts against Plasmodium falciparum (3D7) and HFF cells in vitro
From: Wild Egyptian medicinal plants show in vitro and in vivo cytotoxicity and antimalarial activities
Plant Extract | Plant family | Plant part | Mean IC50 (μg/ml) | Mean Selectivity index (SI) | ||
|---|---|---|---|---|---|---|
P. falciparum (3D7) a (±SD) | HFF cells b (±SD) | |||||
Aerva javanica (Burm.f.) Juss. ex Schult. | Amaranthaceae | leaves | > 100 (43.4) | 378.1 (134.0) | > 3.7 | |
Anabasis setifera Moq. | Amaranthaceae | leaves | > 100 | 1263.6 (194.9) | > 12.6 | |
Artemisia judaica L. | Asteraceae | leaves | 20.0 (3.5) | 316.8 (88.8) | 15.8 | |
Calotropis procera (Aiton) Dryand. | aq. | Apocynaceae | flowers | > 100 | 41.5 (22.6) | > 0.4 |
M80% | flowers | > 100 | 2.9 (1.5) | > 0.02 | ||
Carthamus tinctorius L. | Asteraceae | flowers | > 100 | 444.7 (169.5) | > 4.4 | |
Citrullus colocynthis (L.) Schrad. | E70% | Cucurbitaceae | seeds | 51.7 (10.8) | 88.0 (14.3) | 1.7 |
M80% | seeds | 45.9 (23.3) | 65.6 (7.2) | 1.4 | ||
Cleome droserifolia (Forssk.) Delile | Cleomaceae | leaves | 32.1 (3.8) | 370.9 (95.3) | 11.5 | |
Forsskaolea tenacissima L. | Urticaceae | leaves | > 100 | 519.0 (141.9) | > 5.1 | |
Ochradenus baccatus Delile | Resedaceae | fruit | > 100 | 1179. 0 (245.4) | > 11.7 | |
Ocimum basilicum L. (E70%) | Lamiaceae | leaves | > 100 | 252.6 (13.9) | > 2.5 | |
Pulicaria undulata (L.) C.A.Mey. | (E70%) | Asteraceae | flowers | 18.9 (2.8) | 55.5 (10.7) | 2.9 |
(M80%) | flowers | > 100 (38.2) | 197.5 (61.3) | > 1.9 | ||
Trichodesma africanum (L.) Sm. | Boraginaceae | leaves | 11.7 (4.7) | 413.0 (96.9) | 35.2 | |
Vachellia tortilis subsp. raddiana (Savi) Kyal. & Boatwr. | Fabaceae | seeds | 40.0 (2.8) | 554.5 (110.5) | 13.8 | |
Chloroquine | Â | Â | 0.009 | Â | Â | |